RESUMO
This article describes a case of nodular fasciitis with the karyotype 47,XY,+4/46,XY,add(15)(p11.2), t(16;16)(p13.3;p11.2). The presence of clonal chromosomal abnormalities in this case, as well as in three previously reported cases, indicates that nodular fasciitis is a benign neoplasm and not a reactive lesion.
Assuntos
Cromossomos Humanos Par 15/ultraestrutura , Cromossomos Humanos Par 16/ultraestrutura , Fasciite/patologia , Fibroblastos/ultraestrutura , Neoplasias de Tecidos Moles/patologia , Transformação Celular Neoplásica , Bandeamento Cromossômico , Cromossomos Humanos Par 3/ultraestrutura , Células Clonais/ultraestrutura , Fasciite/classificação , Fasciite/genética , Traumatismos da Mão/patologia , Humanos , Cariotipagem , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/classificação , Neoplasias de Tecidos Moles/genética , CicatrizaçãoRESUMO
We report a case of cytokeratin-positive, CD45-negative primary polymorphic centroblastic lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 and kappa light chain, as well as detection of the monoclonal rearrangement of the immunoglobulin heavy chain gene, helped to establish the diagnosis of lymphoma and to rule out an initially favored diagnosis of poorly differentiated carcinoma.
Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico , Queratinas/análise , Antígenos Comuns de Leucócito/análise , Linfoma/diagnóstico , Neoplasias das Glândulas Suprarrenais/patologia , Idoso , Antígenos CD20/análise , Nucléolo Celular/patologia , Núcleo Celular/patologia , Cromatina/patologia , Citoplasma/patologia , Rearranjo Gênico , Humanos , Cadeias Pesadas de Imunoglobulinas/genética , Cadeias kappa de Imunoglobulina/análise , Imuno-Histoquímica , Linfoma/patologia , Masculino , Tomografia Computadorizada por Raios XRESUMO
We describe a case of botryoid rhabdomyosarcoma with the karyotype 53,XX,+2,+5,+8,+12,+13, i(17)(q10),+19,+20. Only two cytogenetically analyzed cases of this tumor were previously reported and structural chromosomal abnormalities in each tumor were different.
Assuntos
Aberrações Cromossômicas/genética , Cromossomos Humanos Par 17/genética , Isocromossomos/genética , Rabdomiossarcoma/genética , Neoplasias Vaginais/genética , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Aberrações Cromossômicas/patologia , Transtornos Cromossômicos , Análise Citogenética , Feminino , Humanos , Prognóstico , Rabdomiossarcoma/tratamento farmacológico , Rabdomiossarcoma/patologia , Neoplasias Vaginais/tratamento farmacológico , Neoplasias Vaginais/patologiaRESUMO
We describe a case of low-grade myxofibrosarcoma with the karyotype 46,XX,t(2;15)(p23;q21.2), del(7)(q?11.2q?22). Only six of these tumors have been previously studied and all were cytogenetically different.
Assuntos
Cromossomos Humanos Par 15 , Cromossomos Humanos Par 2 , Cromossomos Humanos Par 7 , Fibrossarcoma/genética , Deleção de Genes , Translocação Genética , Idoso , Neoplasias Ósseas/secundário , Neoplasias Ósseas/cirurgia , Mapeamento Cromossômico , Feminino , Fibrossarcoma/patologia , Fibrossarcoma/secundário , Fibrossarcoma/cirurgia , Humanos , Cariotipagem , Neoplasias Musculares/secundário , Neoplasias Musculares/cirurgia , Recidiva Local de Neoplasia/genética , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgia , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
A case of sclerosing epithelioid fibrosarcoma was studied. The tumor cells expressed vimentin, focally epithelial membrane antigen and CD34, contained cisternae of rough endoplasmic reticulum, large Golgi apparatus, many pinocytotic vesicles, and were devoid of basal lamina. Their composite karyotype was 45,Y,t(X;6)(q13;q15), t(6;13)(p11.2;q13),-22¿2/46,Y,t(X;6)(q13;q15),add(13)(p12), add(22)(q13)¿3/44 approximately 46,der(X)t(X;6)(q13;q21),-Y, t(13;14)(q10;q10),-22,add(22)(q13)¿7/46,XY¿8.
Assuntos
Fibrossarcoma/patologia , Neoplasias de Tecidos Moles/patologia , Antígenos CD34/análise , Biomarcadores Tumorais/análise , Cromossomos Humanos Par 12/genética , Células Clonais , Fibrossarcoma/química , Fibrossarcoma/classificação , Fibrossarcoma/imunologia , Amplificação de Genes , Humanos , Cariotipagem , Antígeno Ki-67/análise , Perna (Membro) , Masculino , Pessoa de Meia-Idade , Proteínas de Neoplasias/análise , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/imunologia , Transativadores/genéticaRESUMO
Clinically diagnosed metastasis to the thyroid gland is rare. The authors present the first reported case of metastasis to the thyroid gland from a primary adenocarcinoma of the uterine cervix.
Assuntos
Adenocarcinoma/secundário , Neoplasias da Glândula Tireoide/secundário , Neoplasias do Colo do Útero/patologia , Feminino , Hemorragia/etiologia , Humanos , Pessoa de Meia-Idade , Vagina/patologiaRESUMO
A case of malignant rhabdoid tumor of the liver associated with hypercalcemia of malignancy was studied. The karyotype of the liver primary was 46,XY,t(8;13)(q24.2;q33)[7]/46,XY[13], and of the brain metastasis 46,XY,t(8;13)(q24;q33)[5]/46,XY,t(7;13)(p14;q22) [3]/46,XY,t(1;2;3)(q25;q21;p21) [2]/46,XY[13], respectively. Band 8q24 was previously reported to be rearranged in two malignant rhabdoid tumors, one renal and one hepatic.
Assuntos
Cromossomos Humanos Par 13/genética , Cromossomos Humanos Par 8/genética , Neoplasias Hepáticas/genética , Tumor Rabdoide/genética , Translocação Genética/genética , Humanos , Hipercalcemia/complicações , Lactente , Cariotipagem , Neoplasias Hepáticas/complicações , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/terapia , Masculino , Tumor Rabdoide/complicações , Tumor Rabdoide/patologia , Tumor Rabdoide/terapiaRESUMO
A solitary fibrous tumor of the pleura was studied. Its karyotype was 46,XY,t(6;17) (p11.2;q23),ins(9;12)(q22;q15q24.1),inv(16)(p13.1q24). The rearrangement of 12q13-15 was also described in a subset of hemangiopericytomas of soft tissue and meninges. Because both types of tumors are morphologically and immunophenotypically quite similar, and because some of them share rearrangement of 12q13-15, the possibility of their histogenetical relatedness should be considered.
Assuntos
Aberrações Cromossômicas , Fibroma/genética , Neoplasias Pleurais/genética , Idoso , Antígenos CD34/metabolismo , Cromossomos Humanos Par 12 , Cromossomos Humanos Par 17 , Cromossomos Humanos Par 6 , Colágeno/metabolismo , Fibroma/patologia , Fibroma/cirurgia , Rearranjo Gênico , Humanos , Masculino , Neoplasias Pleurais/patologia , Neoplasias Pleurais/cirurgia , Translocação Genética , Vimentina/metabolismoAssuntos
Cromossomos Humanos Par 17 , Cromossomos Humanos Par 22 , Dermatofibrossarcoma/genética , Neoplasias Cutâneas/genética , Translocação Genética , Adulto , Mapeamento Cromossômico , Dermatofibrossarcoma/patologia , Dermatofibrossarcoma/ultraestrutura , Feminino , Humanos , Metáfase , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/ultraestruturaRESUMO
We report a case of clear cell sarcoma that arose in the ileum and metastasized to the liver. The tumor cells did not contain melanin or glycogen; expressed S-100 protein, but not HMB45; and contained possible atypical melanosomes when examined by electron microscopy. They carried a clonal chromosomal rearrangement: 50,XY,t(2;7)(q37;q22),+8,+8,+9,+11, t(12;22)(q13;q12). The diagnosis was greatly facilitated by the cytogenetic analysis. The translocation t(12;22)(q13;q12-13) has been reported as specific for clear cell sarcomas.
Assuntos
Neoplasias do Íleo/patologia , Neoplasias Hepáticas/secundário , Sarcoma de Células Claras/secundário , Adulto , Biomarcadores Tumorais , Aberrações Cromossômicas , Citogenética , Humanos , Neoplasias do Íleo/genética , Neoplasias do Íleo/metabolismo , Cariotipagem , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/metabolismo , Masculino , Organelas/ultraestrutura , Proteínas S100/metabolismo , Sarcoma de Células Claras/genética , Sarcoma de Células Claras/metabolismoRESUMO
Seven of 15 gastrointestinal stromal tumors from the author's file were classified as plexosarcomas when examined by electron microscopy and immunohistochemistry. Electron microscopy was essential for the diagnosis.
Assuntos
Doenças do Sistema Nervoso Autônomo/patologia , Neoplasias Gastrointestinais/patologia , Neoplasias do Sistema Nervoso/patologia , Adulto , Idoso , Antígenos CD34/análise , Feminino , Neoplasias Gastrointestinais/química , Neoplasias Gastrointestinais/ultraestrutura , Humanos , Imuno-Histoquímica , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Neoplasias do Sistema Nervoso/química , Neoplasias do Sistema Nervoso/ultraestrutura , Fosfopiruvato Hidratase/análise , Proteínas S100/análise , Sinaptofisina/análiseRESUMO
A pigmented choroid plexus carcinoma was studied. The pigment was Fontana-positive, and the neoplastic cells focally expressed melanosomal marker HMB45 and contained probable aberrant melanosomes. The tumor was composed of two pseudodiploid clones, having the karyotypes 46,XY,inv(4)(q12q35),t(6;15)(q21;q22),inv(7)(p11.2q22),t(19; 22) (q13.4;q11.2)[15]/46,XY,t(4;14)(q31.1; p11.2),t(12;13)(p11.1;q34)[6]. The available data seem to indicate that rearrangements of 7p11-12, 9q11-12, 15q22, and 19q13.4 may play a role in the development of choroid plexus carcinomas.
Assuntos
Carcinoma/genética , Neoplasias do Plexo Corióideo/genética , Carcinoma/ultraestrutura , Criança , Neoplasias do Plexo Corióideo/ultraestrutura , Humanos , Cariotipagem , Masculino , Microscopia EletrônicaRESUMO
We report a case of inflammatory myofibroblastic tumor (inflammatory pseudotumor) arising in the soft tissue of the right forearm and progressing into frank spindle cell sarcoma after five recurrences and a total span of 12 years. Myofibroblastic nature of the neoplastic spindle cells was shown by electron microscopy and immunohistochemistry. The patient developed multiple pulmonary metastases and died. Although five cases of metastasizing inflammatory myofibroblastic tumors were reported, association of sarcomatous transformation of this entity with metastatic capability was not previously described.
Assuntos
Granuloma de Células Plasmáticas/patologia , Sarcoma/patologia , Neoplasias de Tecidos Moles/patologia , Progressão da Doença , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/secundário , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Recidiva , Sarcoma/secundário , Sarcoma/ultraestrutura , Neoplasias de Tecidos Moles/secundário , Neoplasias de Tecidos Moles/ultraestruturaRESUMO
A case of neuroendocrine carcinomas arising in the form of a mural nodule in an ovarian mucinous cystadenoma is presented. This represents the third case of neuroendocrine carcinoma arising in an ovarian mucinous tumor. The carcinoma cells were moderately to strongly immunoreactive for enolase, keratin, chromogranin, synaptophysin, and focally, neuron-specific enolase, and contained 130-330 nm neurosecretory granules. The patient presented 9 months after surgery with liver metastases and peritoneal implants. She died of disease within 10 months of initial presentation.
Assuntos
Carcinoma Neuroendócrino/secundário , Cistadenoma Mucinoso/patologia , Neoplasias Hepáticas/secundário , Neoplasias Primárias Múltiplas/patologia , Neoplasias Ovarianas/patologia , Neoplasias Peritoneais/secundário , Idoso , Carcinoma Neuroendócrino/cirurgia , Carcinoma Neuroendócrino/ultraestrutura , Cistadenoma Mucinoso/cirurgia , Cistadenoma Mucinoso/ultraestrutura , Evolução Fatal , Feminino , Humanos , Histerectomia , Imuno-Histoquímica , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias Primárias Múltiplas/ultraestrutura , Neoplasias Ovarianas/cirurgia , Neoplasias Ovarianas/ultraestrutura , Neoplasias Peritoneais/diagnóstico por imagem , RadiografiaRESUMO
A case of mesenchymal chondrosarcoma was studied. The tumor was near-tetraploid and the clonal structural chromosomal abnormalities included add(7)(p13), add(22)(q13), markers, and double minutes. The ultrastructural and immunohistochemical findings were consistent with the diagnosis. Strong immunoreactivity for desmin was an unusual, not previously reported, feature of the neoplasm.
Assuntos
Neoplasias Ósseas/genética , Condrossarcoma Mesenquimal/genética , Neoplasias Ósseas/patologia , Neoplasias Ósseas/ultraestrutura , Condrossarcoma Mesenquimal/patologia , Condrossarcoma Mesenquimal/ultraestrutura , Cromossomos Humanos Par 22 , Cromossomos Humanos Par 7 , Humanos , Imuno-Histoquímica , Lactente , Cariotipagem , Masculino , PloidiasRESUMO
Light microscopic and ultrastructural features of a well-differentiated malignant cylindroma are described. The tumor was locally invasive but it neither recurred nor metastasized during the 3 years after surgery. This fact, together with the similar biologic behavior of two previously described, well-differentiated malignant cylindromas, suggests that these tumors possess either low or no metastatic potential.
Assuntos
Adenoma/patologia , Hialina/ultraestrutura , Neoplasias Cutâneas/patologia , Idoso , Idoso de 80 Anos ou mais , Cartilagem/patologia , Meato Acústico Externo/patologia , Neoplasias da Orelha/patologia , Músculos Faciais/patologia , Feminino , Seguimentos , Humanos , Neoplasias Musculares/patologia , Invasividade Neoplásica , Recidiva Local de Neoplasia , Neoplasias Parotídeas/patologiaRESUMO
A case of peritoneal papillary serous carcinoma which developed after total abdominal hysterectomy and bilateral salpingo-oophorectomy for a benign condition is presented. The patient was treated with platinum-based chemotherapy to which she initially responded, but then the tumor progressed. High dose paclitaxel (250 mg/m2) was given. The patient tolerated this treatment well, achieving a rapid partial response with good palliation of symptoms. Paclitaxel should be considered for patients with a platinum resistant peritoneal papillary serous carcinoma.
